Drug-resistant epilepsy with uncontrolled severe seizures — despite state-of-the-art medical treatment — continues to be a major problem for up to 30% of patients with epilepsy.
Although drug resistance may fluctuate in the course of treatment, for most patients, drug resistance seems to be continuous.
Unfortunately, traditional antiepilepticdrugs (AEDs) don’t seem to prevent or reverse drug resistance in most patients.
However, some new add-on AED therapies have shown as much as 50% in seizure reduction.
This research concerns the structural brain lesions that have been associated with drug resistance in epilepsy.
British scientists believe they’ve uncovered the root cause of drug resistant epilepsy through tests on patients’ brain tissue which revealed some seizures are caused by electrical connections between nerve cells instead of chemical ones.
This faulty wiring would explain why traditional drugs are useless and why some patients have to resort to surgery to remove the brain tissue responsible…
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