Type 2 diabetes

Overview

Type 2 diabetes is an impairment in the way the body regulates and uses sugar (glucose) as a fuel. This long-term (chronic) condition results in too much sugar circulating in the bloodstream. Eventually, high blood sugar levels can lead to disorders of the circulatory, nervous and immune systems.

In type 2 diabetes, there are primarily two interrelated problems at work. Your pancreas does not produce enough insulin — a hormone that regulates the movement of sugar into your cells — and cells respond poorly to insulin and take in less sugar.

Type 2 diabetes used to be known as adult-onset diabetes, but both type 1 and type 2 diabetes can begin during childhood and adulthood. Type 2 is more common in older adults, but the increase in the number of children with obesity has led to more cases of type 2 diabetes in younger people.

There’s no cure for type 2 diabetes, but losing weight, eating well and exercising can help you manage the disease. If diet and exercise aren’t enough to manage your blood sugar, you may also need diabetes medications or insulin therapy.

Symptoms

Signs and symptoms of type 2 diabetes often develop slowly. In fact, you can be living with type 2 diabetes for years and not know it. When signs and symptoms are present, they may include:

  • Increased thirst
  • Frequent urination
  • Increased hunger
  • Unintended weight loss
  • Fatigue
  • Blurred vision
  • Slow-healing sores
  • Frequent infections
  • Numbness or tingling in the hands or feet
  • Areas of darkened skin, usually in the armpits and neck

When to see a doctor

See your doctor if you notice any signs or symptoms of type 2 diabetes.

Causes

Type 2 diabetes is primarily the result of two interrelated problems:

  • Cells in muscle, fat and the liver become resistant to insulin. Because these cells don’t interact in a normal way with insulin, they don’t take in enough sugar.
  • The pancreas is unable to produce enough insulin to manage blood sugar levels.

Exactly why this happens is unknown, but being overweight and inactive are key contributing factors.

How insulin works

Insulin is a hormone that comes from the gland situated behind and below the stomach (pancreas). Insulin regulates how the body uses sugar in the following ways:

  • Sugar in the bloodstream triggers the pancreas to secrete insulin.
  • Insulin circulates in the bloodstream, enabling sugar to enter your cells.
  • The amount of sugar in your bloodstream drops.
  • In response to this drop, the pancreas releases less insulin.

The role of glucose

Glucose — a sugar — is a main source of energy for the cells that make up muscles and other tissues. The use and regulation of glucose includes the following:

  • Glucose comes from two major sources: food and your liver.
  • Glucose is absorbed into the bloodstream, where it enters cells with the help of insulin.
  • Your liver stores and makes glucose.
  • When your glucose levels are low, such as when you haven’t eaten in a while, the liver breaks down stored glycogen into glucose to keep your glucose level within a normal range.

In type 2 diabetes, this process doesn’t work well. Instead of moving into your cells, sugar builds up in your bloodstream. As blood sugar levels increase, the insulin-producing beta cells in the pancreas release more insulin. Eventually these cells become impaired and can’t make enough insulin to meet the body’s demands.

In the less common type 1 diabetes, the immune system mistakenly destroys the beta cells, leaving the body with little to no insulin.

Risk factors

Factors that may increase your risk of type 2 diabetes include:

  • Weight. Being overweight or obese is a main risk.
  • Fat distribution. Storing fat mainly in your abdomen — rather than your hips and thighs — indicates a greater risk. Your risk of type 2 diabetes rises if you’re a man with a waist circumference above 40 inches (101.6 centimeters) or a woman with a measurement above 35 inches (88.9 centimeters).
  • Inactivity. The less active you are, the greater your risk. Physical activity helps control your weight, uses up glucose as energy and makes your cells more sensitive to insulin.
  • Family history. The risk of type 2 diabetes increases if your parent or sibling has type 2 diabetes.
  • Race and ethnicity. Although it’s unclear why, people of certain races and ethnicities — including Black, Hispanic, Native American and Asian people, and Pacific Islanders — are more likely to develop type 2 diabetes than white people are.
  • Blood lipid levels. An increased risk is associated with low levels of high-density lipoprotein (HDL) cholesterol — the “good” cholesterol — and high levels of triglycerides.
  • Age. The risk of type 2 diabetes increases as you get older, especially after age 45.
  • Prediabetes. Prediabetes is a condition in which your blood sugar level is higher than normal, but not high enough to be classified as diabetes. Left untreated, prediabetes often progresses to type 2 diabetes.
  • Pregnancy-related risks. Your risk of developing type 2 diabetes increases if you developed gestational diabetes when you were pregnant or if you gave birth to a baby weighing more than 9 pounds (4 kilograms).
  • Polycystic ovary syndrome. Having polycystic ovary syndrome — a common condition characterized by irregular menstrual periods, excess hair growth and obesity — increases the risk of diabetes
  • Areas of darkened skin, usually in the armpits and neck. This condition often indicates insulin resistance.

Complications

Type 2 diabetes affects many major organs, including your heart, blood vessels, nerves, eyes and kidneys. Also, factors that increase the risk of diabetes are risk factors for other serious chronic diseases. Managing diabetes and controlling your blood sugar can lower your risk for these complications or coexisting conditions (comorbidities).

Potential complications of diabetes and frequent comorbidities include:

  • Heart and blood vessel disease. Diabetes is associated with an increased risk of heart disease, stroke, high blood pressure and narrowing of blood vessels (atherosclerosis).
  • Nerve damage (neuropathy) in limbs. High blood sugar over time can damage or destroy nerves, resulting in tingling, numbness, burning, pain or eventual loss of feeling that usually begins at the tips of the toes or fingers and gradually spreads upward.
  • Other nerve damage. Damage to nerves of the heart can contribute to irregular heart rhythms. Nerve damage in the digestive system can cause problems with nausea, vomiting, diarrhea or constipation. For men, nerve damage may cause erectile dysfunction.
  • Kidney disease. Diabetes may lead to chronic kidney disease or irreversible end-stage kidney disease, which may require dialysis or a kidney transplant.
  • Eye damage. Diabetes increases the risk of serious eye diseases, such as cataracts and glaucoma, and may damage the blood vessels of the retina, potentially leading to blindness.
  • Skin conditions. Diabetes may leave you more susceptible to skin problems, including bacterial and fungal infections.
  • Slow healing. Left untreated, cuts and blisters can become serious infections, which may heal poorly. Severe damage might require toe, foot or leg amputation.
  • Hearing impairment. Hearing problems are more common in people with diabetes.
  • Sleep apnea. Obstructive sleep apnea is common in people living with type 2 diabetes. Obesity may be the main contributing factor to both conditions. It’s not clear whether treating sleep apnea improves blood sugar control.
  • Dementia. Type 2 diabetes seems to increase the risk of Alzheimer’s disease and other disorders that cause dementia. Poor control of blood sugar levels is linked to more-rapid decline in memory and other thinking skills. 

Prevention

Healthy lifestyle choices can help prevent type 2 diabetes, and that’s true even if you have biological relatives living with diabetes. If you’ve received a diagnosis of prediabetes, lifestyle changes may slow or stop the progression to diabetes.

A healthy lifestyle includes:

  • Eating healthy foods. Choose foods lower in fat and calories and higher in fiber. Focus on fruits, vegetables and whole grains.
  • Getting active. Aim for 150 or more minutes a week of moderate to vigorous aerobic activity, such as a brisk walk, bicycling, running or swimming.
  • Losing weight. Losing a modest amount of weight and keeping it off can delay the progression from prediabetes to type 2 diabetes. If you have prediabetes, losing 7% to 10% of your body weight can reduce the risk of diabetes.
  • Avoiding inactivity for long periods. Sitting still for long periods can increase your risk of type 2 diabetes. Try to get up every 30 minutes and move around for at least a few minutes.

For people with prediabetes, metformin (Fortamet, Glumetza, others), an oral diabetes medication, may be prescribed to reduce the risk of type 2 diabetes. This is usually prescribed for older adults who are obese and unable to lower blood sugar levels with lifestyle changes.

Diagnosis

Type 2 diabetes is usually diagnosed using the glycated hemoglobin (A1C) test. This blood test indicates your average blood sugar level for the past two to three months. Results are interpreted as follows:

  • Below 5.7% is normal.
  • 5.7% to 6.4% is diagnosed as prediabetes.
  • 6.5% or higher on two separate tests indicates diabetes.

If the A1C test isn’t available, or if you have certain conditions that interfere with an A1C test, your doctor may use the following tests to diagnose diabetes:

Random blood sugar test. Blood sugar values are expressed in milligrams of sugar per deciliter (mg/dL) or millimoles of sugar per liter (mmol/L) of blood. Regardless of when you last ate, a level of 200 mg/dL (11.1 mmol/L) or higher suggests diabetes, especially if you also have signs and symptoms of diabetes, such as frequent urination and extreme thirst.

Fasting blood sugar test. A blood sample is taken after an overnight fast. Results are interpreted as follows:

  • Less than 100 mg/dL (5.6 mmol/L) is normal.
  • 100 to 125 mg/dL (5.6 to 6.9 mmol/L) is diagnosed as prediabetes.
  • 126 mg/dL (7 mmol/L) or higher on two separate tests is diagnosed as diabetes.

Oral glucose tolerance test. This test is less commonly used than the others, except during pregnancy. You’ll need to fast overnight and then drink a sugary liquid at the doctor’s office. Blood sugar levels are tested periodically for the next two hours. Results are interpreted as follows:

  • Less than 140 mg/dL (7.8 mmol/L) is normal.
  • 140 to 199 mg/dL (7.8 mmol/L and 11.0 mmol/L) is diagnosed as prediabetes.
  • 200 mg/dL (11.1 mmol/L) or higher after two hours suggests diabetes.

Screening. The American Diabetes Association recommends routine screening with diagnostic tests for type 2 diabetes in all adults age 45 or older and in the following groups:

  • People younger than 45 who are overweight or obese and have one or more risk factors associated with diabetes
  • Women who have had gestational diabetes
  • People who have been diagnosed with prediabetes
  • Children who are overweight or obese and who have a family history of type 2 diabetes or other risk factors

After a diagnosis

If you’re diagnosed with diabetes, your doctor or health care provider may do other tests to distinguish between type 1 and type 2 diabetes — since the two conditions often require different treatments.

Your health care provider will repeat the test A1C levels at least two times a year and when there are any changes in treatment. Target A1C goals vary depending on your age and other factors. For most people, the American Diabetes Association recommends an A1C level below 7%.

Treatment

Management of type 2 diabetes includes:

  • Healthy eating
  • Regular exercise
  • Weight loss
  • Possibly, diabetes medication or insulin therapy
  • Blood sugar monitoring

These steps will help keep your blood sugar level closer to normal, which can delay or prevent complications.

Healthy eating

Contrary to popular perception, there’s no specific diabetes diet. However, it’s important to center your diet around:

  • A regular schedule for meals and healthy snacks
  • Smaller portion sizes
  • More high-fiber foods, such as fruits, nonstarchy vegetables and whole grains
  • Fewer refined grains, starchy vegetables and sweets
  • Modest servings of low-fat dairy, low-fat meats and fish
  • Healthy cooking oils, such as olive oil or canola oil
  • Fewer calories

Your health care provider may recommend seeing a registered dietitian, who can help you:

  • Identify healthy choices among your food preferences
  • Plan well-balanced, nutritional meals
  • Develop new habits and address barriers to changing habits
  • Monitor carbohydrate intake to keep your blood sugar levels more stable

Physical activity

Exercise is important for losing weight or maintaining a healthy weight. It also helps with regulating blood sugar levels. Talk to your primary health care provider before starting or changing your exercise program to ensure that activities are safe for you.

Aerobic exercise. Choose an aerobic exercise that you enjoy, such as walking, swimming, biking or running. Adults should aim for 30 minutes or more of moderate aerobic exercise on most days of the week, or at least 150 minutes a week. Children should have 60 minutes of moderate to vigorous aerobic exercise daily.

Resistance exercise. Resistance exercise increases your strength, balance and ability to perform activities of daily living more easily. Resistance training includes weightlifting, yoga and calisthenics.

Adults living with type 2 diabetes should aim for two to three sessions of resistance exercise each week. Children should engage in activities that build strength and flexibility at least three days a week. This can include resistance exercises, sports and climbing on playground equipment.

Limit inactivity. Breaking up long bouts of inactivity, such as sitting at the computer, can help control blood sugar levels. Take a few minutes to stand, walk around or do some light activity every 30 minutes.

Weight loss

Weight loss results in better control of blood sugar levels, cholesterol, triglycerides and blood pressure. If you’re overweight, you may begin to see improvements in these factors after losing as little as 5% of your body weight. However, the more weight you lose, the greater the benefit to your health and disease management.

Your health care provider or dietitian can help you set appropriate weight-loss goals and encourage lifestyle changes to help you achieve them.

Monitoring your blood sugar

Your health care provider will advise you on how often to check your blood sugar level to make sure you remain within your target range. You may, for example, need to check it once a day and before or after exercise. If you take insulin, you may need to do this multiple times a day.

Monitoring is usually done with a small, at-home device called a blood glucose meter, which measures the amount of sugar in a drop of your blood. You should keep a record of your measurements to share with your health care team.

Continuous glucose monitoring is an electronic system that records glucose levels every few minutes from a sensor placed under your skin. Information can be transmitted to a mobile device such as your phone, and the system can send alerts when levels are too high or too low.

Diabetes medications

If you can’t maintain your target blood sugar level with diet and exercise, your doctor may prescribe diabetes medications that help lower insulin levels or insulin therapy. Drug treatments for type 2 diabetes include the following.

Metformin (Fortamet, Glumetza, others) is generally the first medication prescribed for type 2 diabetes. It works primarily by lowering glucose production in the liver and improving your body’s sensitivity to insulin so that your body uses insulin more effectively.

Some people experience B-12 deficiency and may need to take supplements. Other possible side effects, which may improve over time, include:

  • Nausea
  • Abdominal pain
  • Bloating
  • Diarrhea

Sulfonylureas help your body secrete more insulin. Examples include glyburide (DiaBeta, Glynase), glipizide (Glucotrol) and glimepiride (Amaryl). Possible side effects include:

  • Low blood sugar
  • Weight gain

Glinides stimulate the pancreas to secrete more insulin. They’re faster acting than sulfonylureas, and the duration of their effect in the body is shorter. Examples include repaglinide and nateglinide. Possible side effects include:

  • Low blood sugar
  • Weight gain

Thiazolidinediones make the body’s tissues more sensitive to insulin. Examples include rosiglitazone (Avandia) and pioglitazone (Actos). Possible side effects include:

  • Risk of congestive heart failure
  • Risk of bladder cancer (pioglitazone)
  • Risk of bone fractures
  • High cholesterol (rosiglitazone)
  • Weight gain

DPP-4 inhibitors help reduce blood sugar levels but tend to have a very modest effect. Examples include sitagliptin (Januvia), saxagliptin (Onglyza) and linagliptin (Tradjenta). Possible side effects include:

  • Risk of pancreatitis
  • Joint pain

GLP-1 receptor agonists are injectable medications that slow digestion and help lower blood sugar levels. Their use is often associated with weight loss, and some may reduce the risk of heart attack and stroke. Examples include exenatide (Byetta, Bydureon), liraglutide (Saxenda, Victoza) and semaglutide (Rybelsus, Ozempic). Possible side effects include:

  • Risk of pancreatitis
  • Nausea
  • Vomiting
  • Diarrhea

SGLT2 inhibitors affect the blood-filtering functions in your kidneys by inhibiting the return of glucose to the bloodstream. As a result, glucose is excreted in the urine. These drugs may reduce the risk of heart attack and stroke in people with a high risk of those conditions. Examples include canagliflozin (Invokana), dapagliflozin (Farxiga) and empagliflozin (Jardiance). Possible side effects include:

  • Risk of amputation (canagliflozin)
  • Risk of bone fractures (canagliflozin)
  • Risk of gangrene
  • Vaginal yeast infections
  • Urinary tract infections
  • Low blood pressure
  • High cholesterol

Other medications your doctor might prescribe in addition to diabetes medications include blood pressure and cholesterol-lowering medications, as well as low-dose aspirin, to help prevent heart and blood vessel disease.

Insulin therapy

Some people who have type 2 diabetes need insulin therapy. In the past, insulin therapy was used as a last resort, but today it may be prescribed sooner if blood sugar targets aren’t met with lifestyle changes and other medications.

Different types of insulin vary on how quickly they begin to work and how long they have an effect. Long-acting insulin, for example, is designed to work overnight or throughout the day to keep blood sugar levels stable. Short-acting insulin might be used at mealtime.

Your doctor will determine what type of insulin is appropriate for you and when you should take it. Your insulin type, dosage and schedule may change depending on how stable your blood sugar levels are. Most types of insulin are taken by injection.

Side effects of insulin include the risk of low blood sugar (hypoglycemia), diabetic ketoacidosis and high triglycerides.

Weight-loss surgery

Weight-loss surgery changes the shape and function of your digestive system. This surgery may help you lose weight and manage type 2 diabetes and other conditions related to obesity. There are various surgical procedures, but all of them help you lose weight by limiting how much food you can eat. Some procedures also limit the amount of nutrients you can absorb.

Weight-loss surgery is only one part of an overall treatment plan. Your treatment will also include diet and nutritional supplement guidelines, exercise and mental health care.

Generally, weight-loss surgery may be an option for adults living with type 2 diabetes who have a body mass index (BMI) of 35 or higher. BMI is a formula that uses weight and height to estimate body fat. Depending on the severity of diabetes or comorbid conditions, surgery may be an option for someone with a BMI lower than 35.

Weight-loss surgery requires a lifelong commitment to lifestyle changes. Long-term side effects include nutritional deficiencies and osteoporosis.

Pregnancy

Women with type 2 diabetes will likely need to change their treatment plans and adhere to diets that carefully controls carbohydrate intake. Many women will need insulin therapy during pregnancy and may need to discontinue other treatments, such as blood pressure medications.

There is an increased risk during pregnancy of developing diabetic retinopathy or a worsening of the condition. If you are pregnant or planning a pregnancy, visit an ophthalmologist during each trimester of your pregnancy, one year postpartum or as advised.

Signs of trouble

Regularly monitoring your blood sugar levels is important to avoid severe complications. Also, be aware of signs and symptoms that may suggest irregular blood sugar levels and the need for immediate care:

High blood sugar (hyperglycemia). Eating certain foods or too much food, being sick, or not taking medications at the right time can cause high blood sugar. Signs and symptoms include:

  • Frequent urination
  • Increased thirst
  • Dry mouth
  • Blurred vision
  • Fatigue
  • Headache

Hyperglycemic hyperosmolar nonketotic syndrome (HHNS). This life-threatening condition includes a blood sugar reading higher than 600 mg/dL (33.3 mmol/L). HHNS may be more likely if you have an infection, are not taking medicines as prescribed, or take certain steroids or drugs that cause frequent urination. Signs and symptoms include:

  • Dry mouth
  • Extreme thirst
  • Drowsiness
  • Confusion
  • Dark urine
  • Seizures

Diabetic ketoacidosis. Diabetic ketoacidosis occurs when a lack of insulin results in the body breaking down fat for fuel rather than sugar. This results in a buildup of acids called ketones in the bloodstream. Triggers of diabetic ketoacidosis include certain illnesses, pregnancy, trauma and medications — including the diabetes medications called SGLT2 inhibitors.

Although diabetic ketoacidosis is usually less severe in type 2 diabetes, the toxicity of the acids can be life-threatening. In addition to the signs and symptoms of hypoglycemia, such as frequent urination and increased thirst, ketoacidosis may result in:

  • Nausea
  • Vomiting
  • Abdominal pain
  • Shortness of breath
  • Fruity-smelling breath

Low blood sugar. If your blood sugar level drops below your target range, it’s known as low blood sugar (hypoglycemia). Your blood sugar level can drop for many reasons, including skipping a meal, unintentionally taking more medication than usual or being more physical activity than usual. Signs and symptoms include:

  • Sweating
  • Shakiness
  • Weakness
  • Hunger
  • Irritability
  • Dizziness
  • Headache
  • Blurred vision
  • Heart palpitations
  • Slurred speech
  • Drowsiness
  • Confusion

If you have signs or symptoms of low blood sugar, drink or eat something that will quickly raise your blood sugar level — fruit juice, glucose tablets, hard candy or another source of sugar. Retest your blood in 15 minutes. If levels are not at your target, repeat the sugar intake. Eat a meal after levels return to normal.

If you lose consciousness, you will need to be given an emergency injection of glucagon, a hormone that stimulates the release of sugar into the blood.

ou will also receive regular diagnostic tests to screen for complications of diabetes or comorbid conditions.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

Careful management of type 2 diabetes can reduce your risk of serious — even life-threatening — complications. Consider these tips:

  • Commit to managing your diabetes. Learn all you can about type 2 diabetes. Make healthy eating and physical activity part of your daily routine.
  • Work with your team. Establish a relationship with a diabetes educator, and ask your diabetes treatment team for help when you need it.
  • Identify yourself. Wear a necklace or bracelet that says you are living with diabetes, especially if you take insulin or other blood sugar-lowering medication.
  • Schedule a yearly physical exam and regular eye exams. Your regular diabetes checkups aren’t meant to replace regular physicals or routine eye exams.
  • Keep your vaccinations up to date. High blood sugar can weaken your immune system. Get a flu shot every year. Your health care provider may also recommend the pneumonia vaccine. The Centers for Disease Control and Prevention (CDC) also recommends the hepatitis B vaccination if you haven’t previously received this vaccine and you’re 19 to 59 years old.
  • Take care of your teeth. Diabetes may leave you prone to more-serious gum infections. Brush and floss your teeth regularly and schedule recommended dental exams. Consult your dentist right away if your gums bleed or look red or swollen.
  • Pay attention to your feet. Wash your feet daily in lukewarm water, dry them gently, especially between the toes, and moisturize them with lotion. Check your feet every day for blisters, cuts, sores, redness and swelling. Consult your health care provider if you have a sore or other foot problem that isn’t healing.
  • Keep your blood pressure and cholesterol under control. Eating healthy foods and exercising regularly can go a long way toward controlling high blood pressure and cholesterol. Take medication as prescribed.
  • If you smoke or use other types of tobacco, ask your health care provider to help you quit. Smoking increases your risk of various diabetes complications. Talk to your health care provider about ways to stop smoking tobacco.
  • Use alcohol sparingly. Depending on the type of drink, alcohol may lower or raise blood sugar levels. If you choose to drink alcohol, only do so with a meal. The recommendation is no more than one drink daily for women and no more than two drinks daily for men. Check your blood sugar frequently after consuming alcohol.

Alternative medicine

Many alternative medicine treatments claim to help people living with diabetes. According to the National Center for Complementary and Integrative Health, studies haven’t provided enough evidence to recommend any alternative therapies for blood sugar management. Research has shown the following results about popular supplements for type 2 diabetes:

  • Chromium supplements have been shown to have few or no benefits. Large doses can result in kidney damage, muscular problems and skin reactions.
  • Magnesium supplements have shown benefits for blood sugar control in some but not all studies. Side effects include diarrhea and cramping. Very large doses — more than 5,000 mg a day — can be fatal.
  • Cinnamon, in some studies, has lowered fasting glucose levels but not A1C levels. Therefore, there’s no evidence of overall improved glucose management. Most cinnamon contains a substance called coumarin that may cause or worsen liver disease.

Talk to your doctor before starting a dietary supplement or natural remedy. Do not replace your prescribed diabetes medication with alternative medicines.

Coping and support

Type 2 diabetes is a serious disease, and following your diabetes treatment plan takes round-the-clock commitment. To meet the demands of diabetes management, you may need a good support network.

Anxiety and depression are common in people living with diabetes. Talking to a counselor or therapist may help you cope with the lifestyle changes or stressors that come with a type 2 diabetes diagnosis.

Support groups can be good sources of diabetes education, emotional support, and helpful information, such as how to find local resources or where to find carbohydrate counts for a favorite restaurant. If you’re interested, your health care provider may be able to recommend a group in your area.

You can visit the American Diabetes Association website to check out local activities and support groups for people living with type 2 diabetes. The American Diabetes Association also offers online information and online forums where you can chat with others who are living with diabetes. You can also call the organization at 800-DIABETES (800-342-2383).

Preparing for your appointment

Keeping your annual wellness visits enables your health care provider to screen for diabetes and to monitor and treat conditions that increase your risk of diabetes — such as high blood pressure, high cholesterol or a high BMI.

If you are seeing your health care provider because of symptoms that may be related to diabetes, you can prepare for your appointment by being ready to answer the following questions:

  • When did your symptoms begin?
  • Does anything improve the symptoms or worsen the symptoms?
  • What medicines do you take regularly, including dietary supplements and herbal remedies?
  • What are your typical daily meals? Do you eat between meals or before bedtime?
  • How much alcohol do you drink?
  • How much daily exercise do you get?
  • Is there a history of diabetes in your family?

If you are diagnosed with diabetes, your health care provider will begin a treatment plan. You may be referred to a doctor who specializes in hormonal disorders (endocrinologist). Your care team may also include the following specialists:

  • Dietitian
  • Certified diabetes educator
  • Foot doctor (podiatrist)
  • Doctor who specializes in eye care (ophthalmologist)

Talk to your health care provider about referrals to other specialists who will be providing care.

Questions for ongoing appointments

Before any appointment with a member of your treatment team, make sure you know whether there are any restrictions, such as fasting before taking a test. Questions that you should regularly review with your doctor or other members of the team include:

  • How often do I need to monitor my blood sugar, and what is my target range?
  • What changes in my diet would help me better manage my blood sugar?
  • What is the right dosage for prescribed medications?
  • When do I take the medications? Do I take them with food?
  • How is management of diabetes affecting treatment for other conditions? How can I better coordinate treatments or care?
  • When do I need to make a follow-up appointment?
  • Under what conditions should I call you or seek emergency care?
  • Are there brochures or online sources you recommend?
  • Are there resources available if I’m having trouble paying for diabetes supplies?

What to expect from your doctor

Your provider is likely to ask you a number of questions at regularly scheduled appointments, including:

  • Do you understand your treatment plan and feel confident you can follow it?
  • How are you coping with diabetes?
  • Have you experienced any low blood sugar?
  • Do you know what to do if your blood sugar is too low or too high?
  • What’s a typical day’s diet like?
  • Are you exercising? If so, what type of exercise? How often?
  • Do you sit for long periods of time?
  • What challenges are you experiencing in managing your diabetes?

Schizophrenia

Key facts

  • Schizophrenia is a chronic and severe mental disorder affecting 20 million people worldwide (1).
  • Schizophrenia is characterized by distortions in thinking, perception, emotions, language, sense of self and behaviour. Common experiences include hallucinations (hearing voices or seeing things that are not there) and delusions (fixed, false beliefs).
  • Worldwide, schizophrenia is associated with considerable disability and may affect educational and occupational performance.
  • People with schizophrenia are 2-3 times more likely to die early than the general population (2). This is often due to preventable physical diseases, such as cardiovascular disease, metabolic disease and infections.
  • Stigma, discrimination and violation of human rights of people with schizophrenia is common.
  • Schizophrenia is treatable. Treatment with medicines and psychosocial support is effective.
  • Facilitation of assisted living, supported housing and supported employment are effective management strategies for people with schizophrenia.

Symptoms

Schizophrenia is a psychosis, a type of mental illness characterized by distortions in thinking, perception, emotions, language, sense of self and behaviour. Common experiences include:

  • hallucination: hearing, seeing or feeling things that are not there;
  • delusion: fixed false beliefs or suspicions not shared by others in the person’s culture and that are firmly held even when there is evidence to the contrary;
  • abnormal behaviour: disorganised behaviour such as wandering aimlessly, mumbling or laughing to self, strange appearance, self-neglect or appearing unkempt;
  • disorganised speech: incoherent or irrelevant speech; and/or
  • disturbances of emotions: marked apathy or disconnect between reported emotion and what is observed such as facial expression or body language.

Magnitude and impact

Schizophrenia affects 20 million people worldwide but is not as common as many other mental disorders. Schizophrenia also commonly starts earlier among men.

Schizophrenia is associated with considerable disability and may affect educational and occupational performance.

People with schizophrenia are 2 – 3 times more likely to die early than the general population (2). This is often due to physical illnesses, such as cardiovascular, metabolic and infectious diseases.

Stigma, discrimination and violation of human rights of people with schizophrenia is common.

Causes of schizophrenia

Research has not identified one single factor. It is thought that an interaction between genes and a range of environmental factors may cause schizophrenia.

Psychosocial factors may also contribute to schizophrenia.

Services

More than 69% of people with schizophrenia are not receiving appropriate care (3). Ninety per cent of people with untreated schizophrenia live in low- and middle- income countries. Lack of access to mental health services is an important issue. Furthermore, people with schizophrenia are less likely to seek care than the general population.

Management

Schizophrenia is treatable. Treatment with medicines and psychosocial support is effective. However, most people with chronic schizophrenia lack access to treatment.

There is clear evidence that old-style mental hospitals are not effective in providing the treatment that people with mental disorders need and violate basic human rights of persons with mental disorders. Efforts to transfer care from mental health institutions to the community need to be expanded and accelerated. The engagement of family members and the wider community in providing support is very important.

Programmes in several low- and middle- income countries (e.g. Ethiopia, Guinea-Bissau, India, Iran, Pakistan and United Republic of Tanzania) have demonstrated the feasibility of providing care to people with severe mental illness through the primary health-care system by:

  • training primary health-care personnel;
  • providing access to essential drugs;
  • supporting families in providing home care;
  • educating the public to decrease stigma and discrimination;
  • enhancing independent living skills through recovery-oriented psychosocial interventions (e.g. life skills training, social skills training) for people with schizophrenia and for their families and/or caregivers; and
  • facilitating independent living, if possible, or assisted living, supported housing and supported employment for people with schizophrenia. This can act as a base for people with schizophrenia to achieve recovery goals. People affected by schizophrenia often face difficulty in obtaining or retaining normal employment or housing opportunities.

Human rights violations

People with schizophrenia are prone to human rights violations both inside mental health institutions and in communities. Stigma of the disorder is high. This contributes to discrimination, which can in turn limit access to general health care, education, housing and employment.

WHO response

WHO’s Mental Health Gap Action Programme (mhGAP), launched in 2008, uses evidence-based technical guidance, tools and training packages to expand service in countries, especially in resource-poor settings. It focuses on a prioritized set of conditions, directing capacity building towards non-specialized health-care providers in an integrated approach that promotes mental health at all levels of care. Currently mhGAP is being implemented in more than 100 WHO Member States.

The WHO QualityRights Project involves improving the quality of care and human rights conditions in mental health and social care facilities and to empower organizations to advocate for the health of people with mental disorders.WHO’s Mental Health Action Plan 2013-2020, endorsed by the World Health Assembly in 2013, highlights the steps required to provide appropriate services for people with mental disorders including schizophrenia. A key recommendation of the Action Plan is to shift services from institutions to the community.

Diagnosing multiple sclerosis

It can be hard to tell whether your symptoms might be caused by multiple sclerosis (MS) at first, as some of the symptoms can be quite vague or similar to other conditions.

See your GP if you think you have symptoms of MS. Letting them know about the type and pattern of symptoms you’re experiencing in detail will help them determine whether you might have the condition.

If your GP thinks you could have MS, you should see a neurologist (a specialist in conditions of the nervous system) for a specialist assessment.

Tests for MS

Diagnosing MS is complicated because no single test can positively diagnose it. Other possible causes of your symptoms may need to be ruled out first.

It may also not be possible to confirm a diagnosis if you have had only one “attack” of MS-like symptoms. A diagnosis can only be made with confidence once there’s evidence of at least two separate attacks, although this may include signs of attacks on an MRI scan that you may not realise you have had.

Some of the tests you may need to confirm MS are outlined below.

Neurological examination

Your neurologist will look for abnormalities, changes or weakness in your vision, eye movements, hand or leg strength, balance and co-ordination, speech and reflexes.

These may show whether your nerves are damaged in a way that might suggest MS. 

Magnetic resonance imaging (MRI) scan

magnetic resonance imaging (MRI) scan is a painless scan that uses strong magnetic fields and radio waves to produce detailed images of the inside of the body.

It can show whether there’s any damage or scarring of the myelin sheath (the layer surrounding your nerves) in your brain and spinal cord. Finding this can help confirm a diagnosis in most people with MS.

A standard MRI scanner is like a large tube or tunnel. The machine is noisy and some people feel claustrophobic while the scan is done. Tell your neurologist if you’re worried about this.

Newer scanners are more open and work quicker than those used in the past, and most people have scans without any problems. 

Evoked potential test

There are several types of evoked potential test.

The most common type assesses how well the eyes work. Light patterns are shown to the eyes while your brainwaves are monitored using small, sticky patches called electrodes placed on your head.

It’s a painless test and can show whether it takes your brain longer than normal to receive messages.

Lumbar puncture

A lumbar puncture is a procedure to remove a sample of your spinal fluid by inserting a needle into the lower back. Spinal fluid is the fluid that surrounds your brain and spinal cord, and changes in the fluid can suggest problems with the nervous system.

The procedure is done under local anaesthetic, which means you’ll be awake, but the area the needle goes in will be numbed. The sample is then tested for immune cells and antibodies, which is a sign that your immune system has been fighting a disease in your brain and spinal cord.

Lumbar punctures are very safe, but are often uncomfortable and can cause a headache that occasionally lasts for up to a few days.

A lumbar puncture will often be performed to provide extra information if your symptoms or scans are unusual.

Blood tests

Blood tests are usually performed to rule out other causes of your symptoms, such as vitamin deficiencies or a very rare, but potentially very similar, condition called neuromyelitis optica.

Determining the type of MS

Once a diagnosis of MS has been made, your neurologist may be able to identify which type of MS you have.

This will largely be based on:

  • the pattern of your symptoms – such as whether you experience periods when your symptoms get worse (relapses) then improve (remissions), or whether they get steadily worse (progress)
  • the results of an MRI scan – such as whether there’s evidence that lesions in your nervous system have developed at different times and at different places in your body

However, the type of MS you have often only becomes clear over time because the symptoms of MS are so varied and unpredictable. It can take a few years to make an accurate diagnosis of progressive MS, as the condition usually worsens slowly.

Brain Abscess

Photo by Anna Shvets on Pexels.com

What is a Brain Abscess?

A brain abscess is a collection of pus enclosed in the brain tissue, caused by a bacterial or fungal infection. A brain abscess can develop as a complication of an infection, trauma or surgery. They are rare, although people with weakened immune systems (such as people with HIV or those who have received an organ transplant) are more likely to get a brain abscess. 

This type of infection usually begins in one of these ways: 

  • It spreads from a nearby site, such as a middle ear infection, sinus infection or dental abscess.  
  • Blood carries the infection from further away in the body to the brain.  
  • Infectious organisms enter the brain through a penetrating injury, such as a gunshot wound, or from neurosurgical procedures or facial trauma. 

Symptoms

Symptoms vary depending on the size and location of the abscess. More than 75% of people with a brain abscess have a dull, achy headache. For many people this is the only symptom. The pain usually is limited to the side of the brain where the abscess is, and the pain usually becomes worse until the abscess is treated. Aspirin and other pain medication do not relieve the pain. 

About half of the people with a brain abscess have a low-grade fever. Other symptoms may include nausea and vomiting, neck stiffness, seizures, personality changes and muscular weakness on one side of the body.

Diagnosis

Diagnosing a brain abscess is not easy because the early symptoms are so general. For example, many things can cause headaches. For this reason, the diagnosis of brain abscess is usually delayed until about two weeks after symptoms first develop. In some cases, people with brain abscesses develop seizures or neurological changes, such as muscle weakness on one side of the body, before the diagnosis is made.  

If your doctor is concerned you have a brain abscess, he or she will ask about your medical and travel history to determine your risk of having certain infections. The doctor also will ask if you have any of the symptoms of brain abscess. If you do, he or she will ask when they started, how they’ve progressed, and whether you’ve had a recent infection or any trauma that could predispose you to a brain abscess. 

To diagnose a brain abscess, you will need diagnostic tests, such as computed tomography (CT) or magnetic resonance imaging (MRI) scans. These provide pictures of the inside of the brain. The abscess will appear as one or more spots. Blood and other body fluids may be studied to find the original source of the infection. If the diagnosis remains uncertain, a neurosurgeon can remove a piece of the brain abscess with a fine needle. 

Expected Duration

A brain abscess can grow very quickly, typically becoming fully formed within about two weeks. Your doctor will begin treatment immediately after you are diagnosed. Prompt medical attention is the key to relieving your symptoms more quickly and minimizing damage to your long-term health. Surgical drainage of the abscess is often necessary as well. 

Prevention

Some brain abscesses are related to poor dental hygiene or complex sinus infections.  You should floss daily, brush your teeth properly and visit your dentist regularly. Treat sinus infections with decongestants. If symptoms of a sinus or dental infection persist, you may need an antibiotic.  

People with untreated HIV infection are at increased risk of brain abscess. Prevent HIV by practicing safe sex. If you have HIV, you substantially reduce your chance of developing a brain abscess by taking anti-viral medications regularly.

Treatment

Treatment of a brain abscess typically requires a two-pronged approach:  

  • Treating the infection with antibiotics — If the specific type of bacterium is known, a targeted antibiotic is used; otherwise, broad-spectrum antibiotics are given to kill a large number of possible infectious agents. Antibiotics usually are continued for six weeks or more to make sure that the infection is eliminated. 
  • Draining or removing the abscess — If the abscess can be reached easily and there is little danger of damaging the brain, the abscess may be surgically removed. In other cases, the abscess is drained, either by cutting it or by inserting a needle.  

To confirm that the treatment was successful, you will be monitored by magnetic resonance imaging (MRI) or computed tomography (CT) scans to view the brain and abscess. If seizures are a problem you may need anticonvulsant medications, which may continue even after the abscess has been successfully treated.  

When To Call A Professional

See your doctor if you experience a nearly constant headache that gets worse over several days or weeks. If you also have nausea, vomiting, seizures, personality changes or muscle weakness, seek emergency care. 

Prognosis

Without treatment, a brain abscess can be fatal. Most people with a brain abscess are treated successfully. Unfortunately, long-term neurological problems are common even after the abscess is removed and the infection is treated. For example, there may be lingering problems with body function, personality changes or seizures due to scarring or other damage to the brain. 

Learn more about Brain Abscess

Associated drugs

Complex Partial Seizures

Overview

A complex partial seizure is also known as a focal impaired awareness seizure or a focal onset impaired awareness seizure. This type of seizure starts in a single area of the brain. This area is usually, but not always, the temporal lobe of the brain.

While it’s most common in people with epilepsy, this type of seizure has been known to occur in people with cerebral palsy. It includes uncontrolled movement of limbs or other body parts. These seizures are usually very short, and the person having the seizure will be unaware of their surroundings. They may also become unconscious for a brief period of time.

Complex partial seizures and epilepsy

For those with epilepsy, this is the most common type of seizure. But while complex partial seizures are often related to epilepsy, this is not the only reason for someone to have seizures.

Symptoms of complex partial seizures

A complex partial seizure can have multiple possible symptoms. However, these symptoms may occur during one seizure and not another. Complex partial seizures normally only last a few minutes. Seizures beginning in the frontal lobe area of the brain are usually shorter than those that start in the temporal lobe area.

Symptoms will often start abruptly, and the person experiencing the seizure may not know they have had one. The person may:

  • stare blankly or look like they’re daydreaming
  • be unable to respond
  • wake from sleep suddenly
  • swallow, smack their lips, or otherwise move their mouth repetitively
  • pick at things like the air, clothing, or furniture
  • say words repetitively
  • scream, laugh, or cry
  • perform actions that can cause potential danger to themselves, like walking in front of moving cars or removing all or portions of their clothing
  • perform movements like they are riding a bicycle
  • be unaware, either partially or totally, of their surroundings
  • hallucinate
  • try to hurt themselves
  • experience confusion when the seizure ends
  • be unable to remember the seizure when it’s over

Causes of complex partial seizures

While epilepsy is one of the most common causes, there are other conditions that can cause a complex partial seizure. Some of these conditions are:

  • psychological distress or trauma
  • neurologic conditions
  • extreme stress
  • anxiety and depression
  • autism
  • other medical conditions related to the brain
  • damage caused prior to birth
  • neurofibromatosis

Common triggers

A complex partial seizure can happen anytime and usually without much warning. They can even occur when the person is in the middle of an activity. Sometimes the person will have an aura right before having a complex partial seizure. An aura is also called a simple partial seizure. It can act as a warning signal that a bigger seizure is coming.

There are some additional factors that can trigger a seizure, including:

  • flashing lights
  • low blood sugar
  • high fever
  • reactions to some medications

Diagnosing a complex partial seizure

Before deciding on treatment, a doctor will need to confirm that a person is having complex partial seizures. The doctor will need as many details as possible from the person having the seizures as well as from someone who has seen these episodes on a number of occasions. The doctor will need to know what happens before, during, and after each episode.

If a doctor suspects a complex partial seizure, they will usually order a diagnostic test to confirm. An electroencephalogram (EEG) may be done initially. However, the EEG will usually need to record a seizure to be accurate. Other tests that may be given to look for any potential cause of the seizures are a CT scan and an MRI. A blood test and neurological exam may be done as well. These may help the doctor find a cause (if there is a recognizable cause) without seeing an actual seizure while testing.

How are they treated and managed?

There are various types of treatment for complex partial seizures once the condition has been diagnosed. The following are some of the possible treatment options:

The type of treatment used is determined by the cause of the seizures, other medical conditions, and other factors.

Associated health conditions

A complex partial seizure can happen to anyone. However, there are some medical conditions that are more prone to these types of seizures. These medical conditions include:

  • epilepsy (most common)
  • cerebral palsy
  • infection in the brain
  • brain injury
  • tumor in the brain
  • stroke
  • some heart conditions

Sometimes a complex partial seizure will happen to someone without any known medical conditions. There is not always a cause that can be determined in some cases of complex partial seizures.

Outlook

Once diagnosed, seizures — including complex partial seizures — can be managed through a variety of treatment options. In some cases, children will outgrow the seizures.

If you think that you or someone you know is having seizures, it’s important to talk to a doctor for proper diagnosis and treatment.

You should contact a medical professional immediately if someone you know is having a seizure and any of the following is true:

  • this is the person’s first seizure
  • the seizure lasts more than five minutes
  • the person has a high fever
  • the person does not become conscious after the seizure is over
  • the person has diabetes
  • the person is or might be pregnant

Last medically reviewed on June 1, 2017